CRIS Projects Details -
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CRIS Projects Details

Project Details

 

IM Clozapine Dose Concentration Analysis

Lead Applicant Name :
Ndaba Mazibuko
Project Type :
Research
Approval Date :
27-Feb-2023
References :
Lay Summary :
Intramuscular (IM) clozapine has significant potential for the treatment of individuals with Treatment Resistant Schizophrenia (TRS), however it remains under-prescribed as data on its pharmacokinetics (PK) and clinical use is limited, and the current formulation is not optimal practically. This study will investigate time-adjusted dose vs plasma concentration for IM clozapine and then for oral clozapine in same patients, comparing these levels within each individual. <br/>

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