Single dose fMRI effects of guanfacine and lisdexamfetamine in ADHD adolescents | C4C

Lisdexamfetamine and guanfacine are two recently licensed medications for ADHD; while there is some evidence that both drugs may be better at reducing ADHD symptoms than existing drugs, we do not know the underlying brain mechanisms of these drugs. We will invite ADHD patients to complete several cognitive tasks that are typically difficult for them while undergoing a functional brain scan (fMRI) under a single dose of lisdexamfetamine, guanfacine, and placebo to investigate the mechanism of action of the single administration of either drug on the brain and how they differ between each other. We will furthermore investigate the comparative effects of either drug on neuropsychological task performance outside the scanner.