A novel TMS-EEG study of Gamma-aminobutyric acid (GABA)ergic and glutamatergic neurotransmission and cognitive control in antipsychotic treatment response in schizophrenia | C4C

  • Applicant: Tsz Suet (Rachel) Chow
  • Project ID: 22-072

We would like to study how Gamma-aminobutyric acid (GABA) and glutamate chemicals in the brain change and the cognitive abilities in patients who take antipsychotics and respond to them and in patients who take antipsychotics but have not responded to them. We will use a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to stimulate GABA and glutamate brain chemicals and record the response of the brain to the stimulation with a neuroimaging technique called electroencephalogram (EEG), and administer thinking ability tests to assess participants’ cognition.

The Clinical Record Interactive Search (CRIS) system is a computer system that allows researchers at the NIHR Maudsley Biomedical Research Centre (BRC) to carry out research using information from South London and Maudsley NHS Foundation Trust clinical records.

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South London and Maudsley NHS Foundation Trust
NIHR Maudsley BRC