COmBining memantine And cholinesterase inhibitors in Lewy body dementia Treatment trial (COBALT) | C4C

Acetylcholinesterase Inhibitors (AChEIs) are commonly used medicines that can help people with Dementia with Lewy Bodies/Parkinsons Disease Dementia (DLB/PDD) by improving day to day functioning and thinking abilities. Another drug which might help is Memantine, which is used to treat moderate to severe confusion in Alzheimer’s disease and may help to improve memory, awareness and the ability to perform daily functions. COBALT is a multi-centre, parallel arm, double-blind, randomised placebo-controlled trial to assess the clinical and cost effectiveness of memantine augmentation in patients with DLB or PDD who are on an acetylcholinesterase inhibitor (AChEI) for 52 weeks with primary outcome assessed at 26 weeks.