Clozapine in Early Pychosis (CLEAR): A Multi-centre, Randomised Controlled Trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings | C4C

  • Applicant: Emilia Loane
  • Project ID: 24-005

CLEAR is a multi-centre randomised controlled effectiveness trial of clozapine compared to treatment as usual (any other oral antipsychotic) for 12 weeks in 260 children and young people with treatment-resistant schizophrenia (12-24 years old). Although clozapine is the only recommended medication for treatment-resistant psychosis, evidence is still lacking for young people < 25 years old. CLEAR was commissioned by NIHR to examine how effective and safe clozapine is compared to oral antipsychotics in this population, in a real world setting.

The Clinical Record Interactive Search (CRIS) system is a computer system that allows researchers at the NIHR Maudsley Biomedical Research Centre (BRC) to carry out research using information from South London and Maudsley NHS Foundation Trust clinical records.

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