Brain macrostructural and molecular underpinnings of clinical phenotypes and their response to pharmacological interventions in real-world populations using ‘imaging-transcriptomics’.

Treatment of neurological and psychiatric conditions has so far been hampered because people in different diagnostic categories often have shared biological origins, shared symptoms and shared treatments. To address this, we aim to: 1. Identify groups of individuals who share similar neurobiological features, regardless of their diagnosis, in a real-world population (SLaM image bank) using a novel methodology that combines brain imaging and genetics analyses; and 2. Within these groups, to test how various aspects of brain structure and genetics predict if someone will respond to a medication or not. Let me know if that is alright.