Emulating the CLEAR Trial: A Target Trial Using Electronic Health Records to Assess the Efficacy and Tolerability of Clozapine vs other antipsychotics in Young People with Treatment-Resistant Psychosis (CLEAR-EHR)

  • Applicant: Cecilia Casetta
  • Project ID: 25-025

Clozapine is the only recommended treatment for treatment-resistant schizophrenia (TRS) but data on young people are still scarse and contradicting. The CLEAR-EHR study is a target trial that aims to estimate the effectiveness of clozapine versus standard antipsychotics (TAU) on clinical outcomes in young people (aged 12–24) with TRS.

The Clinical Record Interactive Search (CRIS) system is a computer system that allows researchers at the NIHR Maudsley Biomedical Research Centre (BRC) to carry out research using information from South London and Maudsley NHS Foundation Trust clinical records.

About

The Clinical Record Interactive Search has been developed in collboration with:

South London and Maudsley NHS Foundation Trust
NIHR Maudsley BRC