Clozapine in combination with LAI

Clozapine is the most effective antipsychotic, but up to 60% of patients treated with clozapine monotherapy will not or only partially respond to treatment. Furthermore, discontinuation rates are up to 60% within 2 years of treatment. To add to this, some patients experience severe withdrawal symptoms when stopping clozapine abruptly. There have been suggestions in the literature that the combination of clozapine with LAI in partial responders can minimize withdrawal symptoms, reduce relapse rates and health care utilization in terms of ED visits and number of hospital admissions – we aim to investigate this in SLaM.