Clozapine-induced obsessive-compulsive symptoms

  • Applicant: Laura Mangiaterra
  • Project ID: 22-077

There is evidence that clozapine can cause obsessive-compulsive symptoms (OCS). Since clozapine is only prescribed for people with treatment resistant psychosis, a possible explanation is that treatment resistant psychosis could be associated with obsbessive-compulsive symptoms unrelated to treatment. This study aims to use CRIS database to answer two questions: a) in patients with treatment resistant psychosis, is the prevalence of OCS greater when taking clozapine than other antypsychotics? b) What are the clinical and demographic predictors of obsessive-compulsive symptoms in clozapine-treated patients?

The Clinical Record Interactive Search (CRIS) system is a computer system that allows researchers at the NIHR Maudsley Biomedical Research Centre (BRC) to carry out research using information from South London and Maudsley NHS Foundation Trust clinical records.

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The Clinical Record Interactive Search has been developed in collboration with:

South London and Maudsley NHS Foundation Trust
NIHR Maudsley BRC