Investigating genetic profiles associated with 'real world' clinical outcomes in psychosis.

  • Applicant: Emma Francis
  • Project ID: 17-082

Aim: To investigate genetic profiles associated with symptom profile, early course and outcome in psychosis. Background: The Clinical Record Interactive Search (CRIS) database provides anonymised data from the full electronic health records of all patients at the South London and Maudsley Trust, and has been enhanced through data linkages with other sources of information (e.g. acute hospital data), as well as through text-mining (e.g. over 70 individual psychotic and affective symptoms). CRIS is linked to the GAP cohort of people with early psychosis which includes genetic assays and provides hitherto unrealised volumes of outcome data beyond those which were collected in examinations. I will work with Prof Stewart, Dr Iyegbe and Dr Ajnakina on a pre-specified project investigating genetic profiles in relation to a clinical outcome derived from CRIS. Genetic profiles will be sought by relating genome-wide signatures to clinical outcome using cutting-edge prediction-modelling tools.

The Clinical Record Interactive Search (CRIS) system is a computer system that allows researchers at the NIHR Maudsley Biomedical Research Centre (BRC) to carry out research using information from South London and Maudsley NHS Foundation Trust clinical records.

About

The Clinical Record Interactive Search has been developed in collaboration with:

South London and Maudsley NHS Foundation Trust
NIHR Maudsley BRC